The body produces three types of estroegen:
Estrone is in equilibrium with Estadiol and therefore can be approximated by knowing the Estradiol level. There is no need to supplement with Estrone. In fact, metabolites of Estrone are thought to be carcinogenic.
Estradiol is the strongest form of estrogen and when deficiency exists it causes symptoms such as hot flashes, night sweats, insomnia, memory loss and emotional lability. It is best supplemented topically because other forms are known to reduce Growth Hormone levels.
Estriol is considered the weakest estrogen is the “protective” estrogen. It is used to treat vaginal dryness/atrophy and as a safe estrogen replacement for breast cancer survivors. It is generally added whenever Estradiol is supplemented in the form of “Biest” (most often in a 1:4 ratio of E2 to E3). Recent medical literature strongly suggests that estriol is most helpful for autoimmune conditions such as multiple sclerosis.
Progesterone is a bio-identical hormone known to block or protect against the proliferative effects of Estrogen (E2). It is protective of breast and endometrial tissue. When replaced in physiologic doses, it stabilizes mood, increases bone mineralization, reduces PMS and post-menopausal symptoms, and decreases cancer risk. It is best supplemented topically or sublingually.
Progestin is used to refer to a group of synthetic progesterones that have high risk effects (increased breast and endometrial cancer risk, heart disease, stroke and pulmonary embolism) since it is more than a single molecule. These are dangerous compounds and should be avoided.
DHEA is an adrenal hormone which may also be converted to testosterone, cortisol, and estrogen. DHEA supplementation in addition to supporting adrenal health/energy metabolism (when low) will readily optimize testosterone levels in women.
The sulfate form of DHEA which cannot be accurately assessed through saliva.
Testoserone is major sex hormone. In males it is produced in the testes and in women it is produced in the adrenal glands and ovaries. It is essential for sexual function, cardio-protection, stamina, muscle strength, bone density and stable sugar metabolism. In males, it is also protects the prostate gland.
Cortisol is the adrenal’s primary glucocorticoid, secreted in a known 24-hr pattern (diurnal rhythm) essential for sugar metabolism and immune modulation. It is foundational for energy production and optimal thyroid function.